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KMID : 0376219740110031051
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Chonnam Medical Journal
1974 Volume.11 No. 3 p.1051 ~ p.1065
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Influence of Bone Cement on Local Bone and Muscle
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Abstract
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Early phase of local changes following insertion of the bone cement was studied. To the hole produced at the medial femoral condyle of normal rabbit and also into the quadriceps femoris muscle, the bone cement and the stainless steel wire of nearly equal size and shape were inserted, and the local histological changes were studied with intervals of one day, two days, one week, two weeks, and four weeks. The followings were the results of this experiment.
1. After insertion of the wire, the local bone showed moderate lymphocytic infiltration for one week and the fibrous tissue developed around the wire from one to two weeks. At four weeks, the regeneration of both the marrow and trabeculae was almost complete.
2. ´With the cement insertion, the infiltration of neutrophil leukocytes continued for two weeks and was more ´pronounced, than that of the wire-group. A delicate membrane could be identified at the interface between the cement and the underlying bone at one week, and at four weeks it was transformed into the fibrous membrane. Within the adjacent bone, the presence of plasmacytes macrophages, and giant cells persisted and the resorption and regeneration were still continuing at four weeks.
3. The local muscular structure showed, after the wire insertion, mild lympho cytic infiltration for one week, and at, the interface of the implant and the host muscle the fibrous tissue encapsulation appeared at one week, proliferated progressively, up to four weeks. Most of the damaged muscle was replaced by the proliferating fibrous tissue at four weeks.
4. The cement insertion caused much more extensive necrosis of the local muscle, compared with that of the wire-group and the intensive infiltration of neutrophil leukocytes persisted up to four weeks. At the interface of the cement the macrophages, giant cells. and plasmacytes were more abundant and remained for longer period. Consequently at four weeks the fibrous replacement. of the local dead muscle was more extensive than that in the wire-group.
5. It follows from the results of this experiment that physiological bond between the cement and the host bone was interfered. definitely by the formation of the fibrous membrane at the´ interface, and the mechanical contact between the implant and the underlying bone would be loosened unless the repair of the local damaged bone has been completed.
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